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Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

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Science  07 Dec 2018:
Vol. 362, Issue 6419, pp. 1177-1182
DOI: 10.1126/science.aap7607

Article Information

vol. 362 no. 6419 1177-1182

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History: 
  • Received for publication August 30, 2017
  • Resubmitted May 31, 2018
  • Accepted for publication October 30, 2018

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Author Information

  1. M. Steklov1,2,*,
  2. S. Pandolfi1,2,*,
  3. M. F. Baietti1,2,*,
  4. A. Batiuk1,2,
  5. P. Carai3,
  6. P. Najm1,2,
  7. M. Zhang4,
  8. H. Jang4,
  9. F. Renzi1,2,
  10. Y. Cai1,2,
  11. L. Abbasi Asbagh1,2,
  12. T. Pastor1,2,
  13. M. De Troyer1,2,
  14. M. Simicek1,2,
  15. E. Radaelli5,
  16. H. Brems5,
  17. E. Legius5,
  18. J. Tavernier6,7,
  19. K. Gevaert6,7,
  20. F. Impens8,
  21. L. Messiaen5,9,
  22. R. Nussinov4,10,
  23. S. Heymans3,11,12,
  24. S. Eyckerman6,7,
  25. A. A. Sablina1,2,
  1. 1VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
  2. 2Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  3. 3Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  4. 4Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
  5. 5Department of Human Genetics, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  6. 6VIB Medical Biotechnology Center, Albert Baertsoenkaai 3, 9000 Ghent, Belgium.
  7. 7Department of Biochemistry, Ghent University, Albert Baertsoenkaai 3, 9000 Ghent, Belgium.
  8. 8VIB Proteomics Core, Albert Baertsoenkaai 3, 9000 Ghent, Belgium.
  9. 9Department of Genetics, University of Alabama, Birmingham, AL 35294, USA.
  10. 10Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
  11. 11Department of Cardiology, CARIM School for Cardiovascular Diseases Faculty of Health, Medicine and Life Sciences, Maastricht University, Netherlands.
  12. 12The Netherlands Heart Institute, Nl-HI, Utrecht, Netherlands.
  1. Corresponding author. Email: anna.sablina{at}kuleuven.vib.be
  1. * These authors equally contributed to this work.

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