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De novo design of self-assembling helical protein filaments

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Science  09 Nov 2018:
Vol. 362, Issue 6415, pp. 705-709
DOI: 10.1126/science.aau3775

Article Information

vol. 362 no. 6415 705-709

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History: 
  • Received for publication June 5, 2018
  • Accepted for publication September 29, 2018

Author Information

  1. Hao Shen1,2,3,*,
  2. Jorge A. Fallas1,2,*,,
  3. Eric Lynch2,*,
  4. William Sheffler1,2,
  5. Bradley Parry4,5,
  6. Nicholas Jannetty5,6,
  7. Justin Decarreau7,
  8. Michael Wagenbach7,
  9. Juan Jesus Vicente7,
  10. Jiajun Chen8,9,
  11. Lei Wang9,10,
  12. Quinton Dowling2,11,
  13. Gustav Oberdorfer1,2,,
  14. Lance Stewart1,
  15. Linda Wordeman7,
  16. James De Yoreo8,9,
  17. Christine Jacobs-Wagner5,6,12,
  18. Justin Kollman2,
  19. David Baker1,2,13,
  1. 1Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  2. 2Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  3. 3Molecular Engineering Ph.D. Program, University of Washington, Seattle, WA 98195, USA.
  4. 4Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  5. 5Microbial Sciences Institute, Yale University, West Haven, CT 06516, USA.
  6. 6Howard Hughes Medical Institute, Yale University, West Haven, CT 06516, USA.
  7. 7Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA.
  8. 8Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
  9. 9Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
  10. 10State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.
  11. 11Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
  12. 12Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06510, USA.
  13. 13Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
  1. Corresponding author. Email: jaf18{at}uw.edu (J.A.F.); dabaker{at}uw.edu (D.B.)
  1. * These authors contributed equally to this work.

  • Present address: Institute of Biochemistry, Graz University of Technology, Graz, Austria.

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