Research Article

High-resolution comparative analysis of great ape genomes

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Science  08 Jun 2018:
Vol. 360, Issue 6393, eaar6343
DOI: 10.1126/science.aar6343

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A spotlight on great ape genomes

Most nonhuman primate genomes generated to date have been “humanized” owing to their many gaps and the reliance on guidance by the reference human genome. To remove this humanizing effect, Kronenberg et al. generated and assembled long-read genomes of a chimpanzee, an orangutan, and two humans and compared them with a previously generated gorilla genome. This analysis recognized genomic structural variation specific to humans and particular ape lineages. Comparisons between human and chimpanzee cerebral organoids showed down-regulation of the expression of specific genes in humans, relative to chimpanzees, related to noncoding variation identified in this analysis.

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