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Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

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Science  21 Apr 2017:
Vol. 356, Issue 6335, pp. 307-311
DOI: 10.1126/science.aab3896

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Safe anaerobic metabolism

Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective by Storz and McClelland). These results provide insight into the adaptations that this strange social rodent has to make for life underground. They also have implications for medical practice, particularly for understanding how to protect tissues from hypoxia.

Science, this issue p. 307; see also p. 248