Research Article

Stellate cells drive maturation of the entorhinal-hippocampal circuit

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Science  17 Mar 2017:
Vol. 355, Issue 6330, eaai8178
DOI: 10.1126/science.aai8178

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The lights go on in order

Grid cells and place cells in the brain function as part of a circuit that helps us figure out where we are in our physical world. Donato et al. examined how that circuit develops in the brains of mice. Expression patterns of doublecortin and parvalbumin revealed that neurons in the circuit mature in the order in which information flows. Maturation of each piece of the circuit depends on excitatory neuronal activity from the preceding portion. Stellate cells, in contrast, follow an endogenous maturation program. The stellate cells are responsible for initiating the circuit's developmental progression.

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