Science Webinar Series

Webinar | Deciphering cancer: The intersection of epigenetics, metabolism, and tumorigenesis

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Science  17 Mar 2017:
Vol. 355, Issue 6330, pp. 1085
DOI: 10.1126/science.355.6330.1085-b

Summary

Epigenetic modifications to DNA and histone proteins are known to regulate metabolic gene expression, which in turn impacts metabolite levels. Conversely, the machinery responsible for modifying DNA and histones at the epigenetic level is highly sensitive to metabolites arising from cellular metabolism. Thus, the metabolic changes associated with oncogenesis may affect the epigenetic machinery, creating a feedback loop that synergistically promotes the progression of cancer. This webinar will examine how, by targeting proteins responsible for the crosstalk between epigenetics and metabolism, we may be able to develop new and effective therapeutic options for cancer treatment.

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